Pharmacokinetics and tissue distribution of anidulafungin in rats.

نویسندگان

  • Bharat Damle
  • Martin Stogniew
  • James Dowell
چکیده

This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 7  شماره 

صفحات  -

تاریخ انتشار 2008